Mikel Arteta has named only one debutant from the start.
Christian Norgaard will begin the match, with Martin Zubimendi left on the bench.
Arrizabalaga is also a substitute.
Kai Havertz has been selected as the starting striker, amid links with Viktor Gyokeres.
Full team: Arsenal XI vs Milan: Raya, White, Saliba, Calafiori, Zinchenko, Norgaard, Rice, Nwaneri, Saka, Havertz, Martinelli.